5H-BENZO[E]PYRIDO[3,2-B][1,4]DIAZEPIN-6(11H)-ONE

Name	5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Synonyms	LS 75 Pirenzepine intermediate product 11H-Pyrido[2,3-b][1,4]benzodiazepine-6(5H)-one 5H-BENZO[E]PYRIDO[3,2-B][1,4]DIAZEPIN-6(11H)-ONE 5H-Benzo[E]Pyrido[3,2-B][1,4]Diazepin-6(11H)-One 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one 5,11-dihydropyrido[2,3-b][1,4]benzodiazepin-6-one 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one 5,11-Dihydro-benzo[e]pyrido[3,2-b][1,4]diazepin-6-one 6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 1,5-dihydro- 6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one,5,11-dihydro- 5,6-Dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one AK-36728
CAS	885-70-1
EINECS	212-944-2
InChI	InChI=1/C12H9N3O/c16-12-8-4-1-2-5-9(8)14-11-10(15-12)6-3-7-13-11/h1-7H,(H,13,14)(H,15,16)

Molecular Formula	C12H9N3O
Molar Mass	211.22
Density	1.275
Melting Point	292-293℃
Boling Point	336℃
Flash Point	157℃
Solubility	DMSO (Slightly), Methanol (Slightly, Heated)
Vapor Presure	0.000119mmHg at 25°C
Appearance	Solid
Color	Light Beige to Beige
pKa	11.58±0.20(Predicted)
Storage Condition	Refrigerator, under inert atmosphere
Refractive Index	1.627
Physical and Chemical Properties	Light yellow crystals. Melting point 283-285 ℃(286-288 ℃).

chemical properties	light yellow crystals. Melting point 283-285 ℃(286-288 ℃).
Use	An intermediate of pipiperidone.
Production method	Use 3-amino-2-chloropyridine and o-nitrobenzoyl chloride to react with the participation of triethylamine to generate 2-chloro-3-(2-nitrobenzoylamino) pyridine, and then reduce it with stannous chloride to obtain 2-chloro-3-(2-aminobenzoylamino) pyridine, the latter heating ring is combined to make the product.

Last Update：2024-04-10 22:29:15